Molecular Neurobiology of Drug Addiction
نویسندگان
چکیده
منابع مشابه
Review Drug Addiction. Part Ii. Neurobiology of Addiction
The drug addiction may be regarded as the disease of the brain reward system. This system, closely related to the system of emotional arousal, is located predominantly in the limbic structures of the brain. Its existence was proved by demonstration of the “pleasure centers,” that were discovered as location from which electrical self-stimulation is readily evoked. The main neurotransmitter invo...
متن کاملOpiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.
Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose massive personal and public health costs. Addictions are chronic relapsing diseases of the brain caused by drug-induced direct effects and persisting neuroadaptations at the epigenetic, mRNA, neuropeptide, neurotransmitter, or protein levels. These neuroadaptations, which can be specific to drug type, and ...
متن کاملMolecular mechanisms of drug addiction.
Regulation of gene expression is one mechanism by which drugs of abuse can induce relatively long-lasting changes in the brain to cause a state of addiction. Here, we focus on two transcription factors, CREB (cAMP response element binding protein) and DeltaFosB, which contribute to drug-induced changes in gene expression. Both are activated in the nucleus accumbens, a major brain reward region,...
متن کاملComputational Approaches to the Neurobiology of Drug Addiction
of powerful mathematical models have been developed over the years by economists to predict the infl uence of economic variables on drug consumption. For sake of brevity we will not discuss these in the present manuscript. Currently, three classes of models have been advanced. Importantly, all of these models have in common to attribute to midbrain dopamine neurons a key, though signifi cantly ...
متن کاملIntroduction. The neurobiology of drug addiction: new vistas
This Royal Society Discussion meeting, held on February 25 and 26 2008, reported fi rst in the Philosophical Transactions of the Royal Society, B, Biological Sciences, (363, 3107– 3286), and now captured by this volume, was intended to mark the enormous scientifi c progress that has been made in this fi eld in the last decade or so, advances which can be measured from the time of a Frontiers Me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 1994
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.1994.37